Active cobalt catalyst for the cleavage of benzyl ether |
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| Authors: | Wang Bo Yin Zhaojun Li Yangbing Yang Ting-Xiang Meng Xiang-Bao Li Zhong-Jun |
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| Institution: | The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China. |
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| Abstract: | An improved method for the deprotection of benzyl ethers using a catalytic amount of Co(2)(CO)(8) in the presence of Me(2)PhSiH and CO (1 atm) is described. The deprotection reaction is compatible with double bond or sulfur-containing substrates. The method also tolerates other functional groups, such as Ac, Piv, and Bz, and shows potential selectivity in perbenzylated monosaccharides. |
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