Efficient organocatalytic cross-aldol reaction between aliphatic aldehydes through their functional differentiation |
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| Authors: | Kano Taichi Sugimoto Hisashi Maruoka Keiji |
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| Affiliation: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. |
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| Abstract: | A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and α-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst. |
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