| IMMOBILIZATION OF Saccharomyces Cerevisiae USING POLY(ACRYLAMIDE)GEL FOR ASYMMETRIC SYNTHESIS OF R(-)-MANDELIC ACID |
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| 作者姓名： | LI Zhongqin GUO Daiping HUANG Xinghua YANG Kai XU Xiaoping** . |
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| 作者单位： | LI Zhongqin1，2 GUO Daiping1 HUANG Xinghua1 YANG Kai1 XU Xiaoping1** 1.Department of Chemical Engineering，Fuzhou University，Fuzhou 350002，China 2.Key Lab.of Industry Biotechnology，Southern Yangtze University，Wuxi 214036，China |
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| 基金项目： | TheNaturalScienceFoundationofFujian(C0410006). |
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| 摘 要： | 1. INTRODUCTIONPoly(acrylamide) hydrogel (PAAm gel), which is able to swell, but cannot be dissolved in the aqueous environment, is a three-dimension network with repeating hydrophilic units -CONH2. Since PAAm gel has a good biocompatibility as well as a high mechanical strength, and can be easily separated from reaction medium, PAAm gel has often been employed to immobilize enzymes and cells so as to catalyze various of chemical and biochemical reactions 1,2]. So far, biosynthesis …
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IMMOBILIZATION OF Saccharomyces Cerevisiae USING POLY(ACRYLAMIDE)GEL FOR ASYMMETRIC SYNTHESIS OF R(-)-MANDELIC ACID |
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| LI Zhongqin, GUO Daiping HUANG Xinghua YANG Kai XU Xiaoping** ..IMMOBILIZATION OF Saccharomyces Cerevisiae USING POLY(ACRYLAMIDE)GEL FOR ASYMMETRIC SYNTHESIS OF R(-)-MANDELIC ACID[J].离子交换与吸附(英文版),2006(1). |
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| Authors: | LI Zhongqin GUO Daiping HUANG Xinghua YANG Kai XU Xiaoping |
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| Institution: | LI Zhongqin1,2 GUO Daiping1 HUANG Xinghua1 YANG Kai1 XU Xiaoping1** 1.Department of Chemical Engineering,Fuzhou University,Fuzhou 350002,China 2.Key Lab.of Industry Biotechnology,Southern Yangtze University,Wuxi 214036,China |
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| Abstract: | In this paper,the poly(acrylamide)hydrogel used to immobilize saccharomyces cerevisiae for asymmetric synthesis of R(-)-mandelic acid was prepared with free radical ploymerization in deionized water at room temperature under nitrogen atmosphere.The influence of the composition of hydrogel,loading amount of cells and culture conditions on the asymmetric synthesis was investigated.Results show that PAAm hydrogel is a feasible carrier for immobilization of cells which is a potential alternative method to prepare enantiomerically pure R(-)-mandelic acid. |
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| Keywords: | Poly(acrylamide)gel Immobilization R(-)-mandelic acid Saccharomyces Cerevisiae |
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