A rapid, one-pot, microwave-influenced synthesis of spiro-2,5-diketopiperazines via a cascade Ugi/6-exo-trig aza-Michael reaction |
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| Authors: | Santra Soumava Andreana Peter R |
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| Affiliation: | Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA. |
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| Abstract: | A rapid, cascade reaction process has been developed to access biologically validated spiro-2,5-diketopiperazines. The facile and environmentally benign method capitalizes on commercially available starting reagents for a sequential Ugi/6-exo-trig aza-Michael reaction, water as a solvent, and microwave irradiation without any extraneous additives. |
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