| Rapid Synthesis of 1,2,3,4-Tetrahydropyrimidin-2-ones Using Zn（NH2SO3）2 as a Catalyst under Microwave Irradiation |
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| 引用本文： | 张珉,李毅群,周美云.Rapid Synthesis of 1,2,3,4-Tetrahydropyrimidin-2-ones Using Zn（NH2SO3）2 as a Catalyst under Microwave Irradiation[J].中国化学,2006,24(2):282-284. |
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| 作者姓名： | 张珉 李毅群 周美云 |
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| 作者单位： | Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 20272018） and the Guangdong Natural Science Foundation （Nos. 021166 and 04010458）. |
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| 摘 要： | Rapid synthesis of 1,2,3,4-tetrahydropyrimidin-2-ones （THPO） from aromatic aldehydes, β-ketoester and urea （or thiourea） using zinc sulfamate as the catalyst under microwave irradiation was described here. Compared with the classical Biginelli reaction, this new method consistently has the advantages of good yields （76%-96%）, short reaction time （3-15 min）, no corrosion to equipments, ease of manipulation, and low cost catalyst.
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| 关 键 词： | 快速合成 1 2 3 4-四氢嘧啶-2-酮 Zn（NH2SO3）2 催化剂 微波照射 Biginelli反应 |
| 收稿时间： | 2005-02-06 |
| 修稿时间： | 2005-02-062005-10-20 |
Rapid Synthesis of 1,2,3,4‐Tetrahydropyrimidin‐2‐ones Using Zn(NH2SO3)2 as a Catalyst under Microwave Irradiation |
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| ZHANG Min, LI Yi-Qun, ZHOU Mei-Yun.Rapid Synthesis of 1,2,3,4‐Tetrahydropyrimidin‐2‐ones Using Zn(NH2SO3)2 as a Catalyst under Microwave Irradiation[J].Chinese Journal of Chemistry,2006,24(2):282-284. |
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| Authors: | ZHANG Min LI Yi-Qun ZHOU Mei-Yun |
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| Institution: | Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, China |
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| Abstract: | Rapid synthesis of 1,2,3,4‐tetrahydropyrimidin‐2‐ones (THPO) from aromatic aldehydes, β‐ketoester and urea (or thiourea) using zinc sulfamate as the catalyst under microwave irradiation was described here. Compared with the classical Biginelli reaction, this new method consistently has the advantages of good yields (76%–96%), short reaction time (3–15 min), no corrosion to equipments, ease of manipulation, and low cost catalyst. |
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| Keywords: | zinc sulfamate catalyst microwave irradiation Biginelli reaction |
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