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Folate-targeted optical and magnetic resonance dualmodality PCL- |
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| Authors: | Xiao-ming Sun Jin-xia Xu Jian-bin Tang Mei-hua Sui You-qing Shen |
| Affiliation: | (1) Department of Research Oncology, Division of Cancer Studies, King’s College London, London, UK;(2) Davy-Faraday Research Laboratory, The Royal Institution of Great Britain, London, W1S 4BS, UK;(3) Department of Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, 3rd Floor Bermondsey Wing, Great Maze Pond, London, SE1 9RT, UK; |
| Abstract: | A biodegradable tumor targeting nano-probe based on poly(ɛ-caprolactone)-b-poly(ethylene glycol) block copolymer (PCL-b-PEG) micelle functionalized with a magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid-gadolinium (DTPA-Gd3+) on the shell and a near-infrared (NIR) dye in the core for magnetic resonance and optical dual-modality imaging was prepared. The longitudinal relaxivity (r 1) of the PCL-b-PEGDTPA-Gd3+ micelle was 13.4 (mmol/L)−1s−1, three folds of that of DTPA-Gd3+, and higher than that of many polymeric contrast agents with similar structures. The in vivo optical imaging of a nude mouse bearing xenografted breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention (EPR) effect. The results indicated that the dualmodality micelle is a promising nano-probe for cancer detection and diagnosis. |
| Keywords: | Dual-modality Polymeric micelle MRI contrast agent Fluorescence Tumor imaging |
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