Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem |
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Authors: | Praveen Kumar Sharma Ankur Fogla B S Rathore and M Kumar |
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Institution: | (1) Department of Chemistry, University of Rajasthan, Jaipur, 302055, India |
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Abstract: | In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization
of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their
analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial
species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged
heterocyclic structural scaffolds. |
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Keywords: | |
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