Chemical modification of plant alkaloids. 6. T-reactions of anabasine derivatives |
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Authors: | K. A. Krasnov V. G. Kartsev |
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Affiliation: | (1) Institute of Toxicology, Russia, 192019 St. Petersburg;(2) Interbioskrin, 142432, Chernogolovka, Moscow Oblast, Institutskii Pr. 8, Russia |
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Abstract: | T-reactions of anabasine derivatives were performed for the first time. Condensation of 5-nitro-2-[2-(3pyridyl)piperidino]benzaldehyde with 1,3-dimethylbarbituric acid formed an annelated tetrahydroquinoline system containing a spiropyrimidine moiety as the T-reaction product. Condensation of this same aldehyde with Meldrum’s acid was accompanied by recyclization that led to opening of the piperidine ring and closing of the tetrahydroquinolone system. A third version of the T-reaction that also led to opening of the piperidine ring but without recyclization was the condensation with dimedone. |
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