一锅法合成3-溴丙基乙酸酯

以1，3-丙二醇、氢溴酸（48％）和冰醋酸为原料，在带水剂的作用下，一锅法合成了3-溴丙基乙酸酯．考察了带水剂及追加醋酸或醋酸酐量对产率的影响，并通过气质联用仪对粗产品进行分析测定，推断其反应机理．结果表明：较适宜的合成条件为1，3-丙二醇0．21mol，1，3-丙二醇与氢溴酸（48％）、冰醋酸摩尔比为1：1：1．3，在带水剂甲苯（21mL）的作用下，反应2．5h，反应结束前1h追加4．8mL醋酸酐，合成效果最好，产率可达到95．7％．

One-pot Synthesis of 3-Bromopropyl Acetate

3-Bromopropyl acetate was synthesized in one pot reaction of trimethylene glycol with an aqueous solution of hydrogen bromide(48 %)and acetic acid(molar ratio,1:1:1.3).The effects of water-carrying agents and the additional quantity of acetic acid or acetic anhydride on the yield were investigated,meanwhile,the crude product was analyzed by GC-MS and the reaction mechanism was proposed.The experimental result showed that the optimal condition was as follows:the molar ratio of trimethylene glycol,hydrogen bromide and acetic acid was 1:1:1.3.When trimethylene glycol was 0.21 mol,refluxed 2.5 h with 21 mL toluene.After 1.5 h,additional 4.8 mL acetic anhydride was added,the yield of 3-bromopropyl acetate was high up to 95.7 %