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Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core-shell nanospheres
Authors:Tao Gen-Ping  Chen Qiu-Yun  Yang Xia  Zhao Kai-Di  Gao Jing
Institution:School of Chemistry and Chemical Engineer, Jiangsu University, Zhenjiang, 212013, PR China.
Abstract:In this report, we aim at optimizing the approach of delivering and imaging cancer cell targeting using anti-proliferative nanoparticle complex. Rhodamine B isothiocyanate doped silica-coated (RBITC-SiO?) were prepared by microemulsion method. Fe(III) complex of di(picolyl)amine was conjugated on to the surface RBITC-SiO? to produce final nanosphere (RBITC-SiO? @dpa-Fe) with an average hydrodynamic diameter of 74 nm. The Fe(III)-di(picolyl)amine complex modified nanospheres displayed enhanced HeLa cells uptake in vitro suggesting selective cancer cell payload delivery. RBITC-SiO? @dpa-Fe also showed reduced off-target cytotoxicity. The conjugate of dpa-Fe(III) complex and fluorescence core-shell nanoparticles RBITC-SiO? represents a class of novel multi-functional nanoparticles that combines the advantages of active cancer-targeting through Fe(III) complex mediated intracellular drug delivery and compatibility with fluorescence imaging.
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