Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened

Authors:	Tao Haiyan Jin Qihui Koo Dong-In Liao Xuebin Englund Nathan P Wang Yan Ramamurthy Arun Schultz Peter G Dorsch Marion Kelleher Joseph Wu Xu

Institution:	Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

Abstract:	Download : Download high-res image (107KB) Download : Download full-size image Highlights? New small molecule antagonists of Smo with distinct binding modes discovered from high throughput screens ? ALLO-1 and ALLO-2 are potent against the drug-resistant mutant of Smo ? ALLO-1 is potent against oncogenic mutant of Smo (SmoM2)

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