| 螺［5．5］十一烷┐3┐酮的合成 |
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| 引用本文： | 冯亚青,,张晓东.螺［5．5］十一烷┐3┐酮的合成[J].天津大学学报(自然科学与工程技术版),1996(4). |
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| 作者姓名： | 冯亚青 张晓东 |
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| 作者单位： | 天津大学制药厂 |
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| 摘 要： | 研究了螺［５．５］十一烷－３－酮新的合成路线，即环己酮１经环氧化生成１－氧杂螺［２．５］辛烷２；２再与路易斯酸作用发生氢重排生成甲酰环己酮３；３与甲基乙烯酮在酸的催化下经迈克尔加成反应得到１－螺［５．５］十一烯－３－酮４；最后经加氢生成目的产物螺［５．５］十一烷－３－酮５，总收率为２８．９％，反应步骤少、操作简单
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| 关 键 词： | 螺［5．5］十一烷－3－酮，氢重排，迈克尔加成 |
INVESTIGATION ON SYNTHESIS OF SPIRO UNDECANE 3 ONE |
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| Feng Yaqing.INVESTIGATION ON SYNTHESIS OF SPIRO UNDECANE 3 ONE[J].Journal of Tianjin University(Science and Technology),1996(4). |
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| Authors: | Feng Yaqing |
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| Institution: | Feng Yaqing(Dept. of Applied Chemistry) Zhang Xiaodong(Pharmaceutical Factory) |
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| Abstract: | A new routine concerning the synthesis of spiroundecan 3 one is proposed. Firstly, the epoxidation of cyclohexanone 1 produces 1 oxaspirooctane 2. By the action of Lewis acid, the hydrogen rearrangement is achieved, yielding cyclohexyl formaldehyde 3. Furthermore, with the catalysis of acid the Michael addition reaction of cyclohexyl formaldehyde with methyl vinyl ketone leads to the spiroundecene 1 one 3 4. Finally, the spiroundecane 3 one is obtained in virtue of the hydrogenation 5. The overall yield was 28.9%. |
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| Keywords: | spiroundecane 3 one hydrogen rearrangement Michacl addition reaction |
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