A Convenient Synthesis of Octahydro-pyrazino [ 1,2- a ] pyrazine

The recent research results suggest that a series of octahydro-pyrazino 1,2-a ]pyrazines are useful as antiallergic agents.1] Gubert et al. 2] developed a route from 1,4-dibenzyl-2-ethoxycarbonylpiperazine for the synthesis of this ring system. Under their conditions, this ring system was obtained with a low overall yield in six steps. Optimization of synthetic route to this ring system is still desirable. In this paper, we presented an efficient synthesis of octahydropyrazino1,2-a]pyrazine by a new and efficient method starting from 1,3-dichloro-2-propanol and N-tosylated diethylenetriamine. The structure of title compound was determined by spectroscopy and X-ray diffraction technique.