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Concluding the Amyloid Formation Pathway of a Coiled‐Coil‐Based Peptide from the Size of the Critical Nucleus |
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| Authors: | Dr Ulla I M Gerling Dr Markus S Miettinen Prof Dr Beate Koksch |
| Institution: | 1. Department of Chemistry and Biochemistry—Organic Chemistry, Freie Universit?t Berlin, Takustrasse 3, 14195 Berlin (Germany);2. Department of Physics, Freie Universit?t Berlin, Arnimallee 14, 14195 Berlin (Germany) |
| Abstract: | The size of the critical nucleus acting as intermediate in the amyloid formation of a model peptide is calculated. The theoretical approach is based on experimentally determined amyloid formation rates and gives new insights into the amyloid formation pathway. |
| Keywords: | amyloid formation coiled coil nucleus peptides theoretical approach |