A near-infrared emissive Al sensing platform for specific detection in solution,cells and probing DNase activity |
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| Authors: | Barun K. Datta Durairaj Thiyagarajan Chirantan Kar Aiyagari Ramesh Gopal Das |
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| Affiliation: | 1. Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India;2. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India |
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| Abstract: | A new tricarbocyanine-based chemosensor exhibited a dramatic Al3+-specific fluorescence turn-on response in the near-infrared (NIR) region. The receptor was found to be highly selective towards Al3+ over other metal ions in physiological condition. The sensor was non-toxic and could thus be employed as an imaging probe for detecting intracellular Al3+ in live cells. Interestingly, upon interaction with DNA in solution, the L–Al3+ ensemble rendered tracking of DNase activity in solution through a systematic reduction in the fluorescence emission intensity. |
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| Keywords: | Near-infrared fluorescence Al3+ sensor Cell imaging DNase activity sensing |
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