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Modified screen printed electrode for development of a highly sensitive label-free impedimetric immunosensor to detect amyloid beta peptides |
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| Authors: | Truong T.N. Lien Yuzuru Takamura Eiichi Tamiya Mun'delanji C. Vestergaard |
| Affiliation: | 1. School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan;2. School of Engineering Physics, Hanoi University of Science and Technology (HUST), No.1 Dai Co Viet, Hai Ba Trung, Hanoi, Viet Nam;3. Department of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan;4. Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Korimoto-1-21-24, Kagoshima City, Kagoshima, 890-0065, Japan |
| Abstract: | Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting approximately 26 million people world-wide, and the number is increasing as life expectancy increases. Since the only reliable diagnosis for the pathology is histochemical post-mortem examination, there is a rather urgent need for reliable, sensitive and quick detection techniques. Amyloid beta, being one of the established and widely accepted biomarkers of AD is a target biomolecule. |
| Keywords: | Amyloid beta (Aβ) Immunosensor Electrochemical impedance spectroscopy (EIS) Screen-printed electrode (SPE) Disposable electrochemical printed (DEP) chip |
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