Solvent-dependent turn-on probe for dual monitoring of Ag and Zn in living biological samples |
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| Authors: | Zheng Yang Mengyao She Bing Yin Likai Hao Martin Obst Ping Liu Jianli Li |
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| Institution: | 1. Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, College of Chemistry & Materials Science, Northwest University, Xi’an, Shaanxi 710069, PR China;2. Center for Applied Geoscience, Institute for Geoscience, Eberhard Karls University Tuebingen, Hoelderlinstr. 12, Tuebingen 72074, Germany;3. College of Chemistry, Beijing Normal University, No. 19, XinJieKouWai St., HaiDian District, Beijing 100875, PR China |
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| Abstract: | A novel, solvent-dependent “off–on” probe with benzoylthiourea moiety as the functional receptor and fluorescein as the fluorophore was designed for monitoring of Ag+ in EtOH–H2O (2:8, v/v) solution and Zn2+ in CH3CN–H2O (2:8, v/v) solution at physiological range with sufficient selectivity and sensitivity. The Ag+ promoted desulfurization of thiosemicarbazide functionality in formation of the 1,3,4-oxadiazole and the coordination of Zn2+ to the O atom and N atom of the spoirolactam moiety and the S atom of the benzoylthiourea moiety were investigated to be the power that promoted the fluorescent enhancement. This probe was tested highly suitable for mapping Ag+ and Zn2+ in living human osteosarcoma MG-63 cells and microbial cell–EPS–mineral aggregates, thus, providing a wonderful candidate for tracking Ag+ and Zn2+ in biological organisms and processes. |
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| Keywords: | Fluorescence Probe Mechanism DFT calculation Bio-imaging |
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