In vivo solid phase microextraction sampling of human saliva for non-invasive and on-site monitoring |
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Authors: | Vincent Bessonneau Ezel BoyaciMalgorzata Maciazek-Jurczyk Janusz Pawliszyn |
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Affiliation: | Department of Chemistry, University of Waterloo, Waterloo, ON N2L 3G1, Canada |
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Abstract: | On-site sample preparation is an analytical approach based on direct sampling from the system under investigation. It has the advantage of combining sampling and sample preparation into a single step, thus generally is fast, minimizes the potential sources of error and eliminates the risks for analytes instability. For such analysis solid phase microextraction in thin film geometry (TF-SPME) can provide robust and convenient in vivo sampling, offering in the same time faster analysis and higher extraction recovery (i.e., better sensitivity) due to large surface to volume ratio. |
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Keywords: | Saliva In vivo sampling Solid-phase microextraction Doping substances Steroids |
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