Zwitterionically modified hydroxypropylcellulose for biomedical applications |
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Authors: | Kamila Gawe? |
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Affiliation: | Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland |
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Abstract: | Novel polyelectrolytes have been synthesized by grafting sulfobetaine side chains onto hydroxypropylcellulose backbone. Polymers with various degrees of grafting have been obtained. The polymers do not interact with model anionic, cationic and zwitterionic surfactants as found in fluorescence studies using pyrene as a molecular probe. Dynamic light scattering (DLS) studies indicated that in the graft polymer solution two types of polymers are present. The films were formed from the grafted polymers. Using atomic force microscopy (AFM) technique it was found that they are resistant to the adhesion of proteins and can be used for the preparation of antiadhesive surfaces which may find biomedical applications. |
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Keywords: | Hydroxypropylcellulose Sulfobetaine Surfactants Proteins Polyelectrolytes |
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