Synthese von 1,1′-Biphenyl-3-carbonsäure-und 3,5-dicarbonsäurederivaten unter Verwendung von Ethoxymethylenmalononitril

Reaction of ethoxymethylenemalononitrile with ethyl 4-phenylacetoacetate leads to ethyl 1,1-biphenyl-6-amino-5-cyano-2-hydroxy-3-carboxylate (3). Acid or basic hydrolysis of the ester and cyano group of3 affords the new derivatives4,5 and6.7 a, b are obtained bySandmeyer-reaction of3. Basic hydrolysis of7 a gives the 3,5-dicarboxylic acid derivative8.