pH-induced release from P2VP-PEO block copolymer vesicles |
| |
Authors: | Borchert Uwe Lipprandt Ute Bilang Matthias Kimpfler Andrea Rank Anja Peschka-Süss Regine Schubert Rolf Lindner Peter Förster Stephan |
| |
Institution: | Institute of Physical Chemistry, University of Hamburg, D-20146 Hamburg, Germany. |
| |
Abstract: | The pH-induced release of hydrophilic dyes from poly(2-vinylpyridine-b-ethylene oxide) (P2VP-PEO) block copolymer vesicles is investigated. The structure of the vesicles is characterized using small-angle neutron scattering (SANS) and cryo-electron microscopy (cryo-TEM). A decrease of the pH below 5 leads to protonation and dissolution of the poly-2-vinylpyridine blocks which induces rupture and dissolution of the vesicle membrane. Details of the rupture, dissolution, and release process are studied by fluorescence video microscopy, gel electrophoresis, and high-performance ultrafiltration. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|