Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS |
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| Authors: | M. Sergi E. Bafile D. Compagnone R. Curini G. D’Ascenzo F. S. Romolo |
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| Affiliation: | (1) Department of Food Science, University of Teramo, Via C. R. Lerici 1, Mosciano S.A., 64023 Teramo, Italy;(2) Department of Chemistry, University of Rome “La Sapienza”, P. le A. Moro 5, 00185 Rome, Italy;(3) Department of Legal Medicine, University of Rome “La Sapienza”, Viale Regina Elena 336, 00161 Rome, Italy;(4) Institut de Police Scientifique, Université de Lausanne, Batiment Batochime, 1015 Lausanne, Switzerland |
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| Abstract: | An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography–tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a TurboIonSpray source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis.  Figure Diverter system |
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| Keywords: | Abuse drugs Liquid chromatography– tandem mass spectrometry Plasma Oral fluids Forensic analytical chemistry |
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