Platinum(II) Mono-N1-(2"-Tetrahydrofuranyl)-5-Fluorouracilate Complexes with Ammonia |
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| Authors: | Mogilevkina M. F. Shipachev V. A. Tkachev S. V. Troshkova G. P. Martynets L. D. |
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| Affiliation: | (1) Novosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russia;(2) Siberian Division, Russian Academy of Sciences, Institute of Inorganic Chemistry, pr. Akademika Lavrent'eva 3, Novosibirsk, 630090, Russia;(3) Vektor State Research Center of Virology and Biotechnology, Novosibirsk, Russia |
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| Abstract: | The reaction between cis-[Pt(NH3)2Cl2], N1-(2"-tetrahydrofuranyl)-5-fluorouracil (HL), and NaOH (taken in a molar ratio of 1 : 1 : 1) or between cis-[Pt(NH3)2Cl2], HL, and Ag2O (taken in the molar ratio of 1 : 1 : 0.5) was used to synthesize complexes Ia (in the case of NaOH) or Ib (in the case of Ag2O) with composition Pt(NH3)2LCl. The model complex [Pt(NH3)3L]NO3 (II) was synthesized by the reaction between [Pt(NH3)3Cl]Cl, HL, AgNO3, and Ag2O (1 : 1 : 1 : 0.5). The obtained compounds were characterized by chemical analysis, chromatography, thermogravimetry, conductometry, potentiometry, IR, electronic, and NMR spectroscopies. Complexes Ia and Ib were found to have both similar and different properties. The structures of the compounds and the type of L– coordination to platinum(II) were suggested. Cytotoxic properties of Iaand Ib were studied. |
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