钴胺素的溶析结晶研究以及离子杂质对晶体生长的影响

采用激光法研究了钴胺素的结晶热力学，包括在不同温度下，不同溶剂配比下的溶解度和超溶解度，介稳区的测定。研究了四种不同的离子杂质(Na+，Mg2+，Ca2+and Fe3+)对钴胺素结晶诱导期的影响。通过实验结果表明钴胺素在溶析结晶过程中，Fe3+和Mg2+要比Na+和Ca2+具有更明显的影响。

Investigation into the crystallization of cobalamine and the influence of ionic impurity on crystal growth

This paper presents an experimental investigation on the crystallization thermodynamics of cobalamine（vitamin B12）and the metastable zone is measured at different solvent ratios and temperatures by laser. The influence of four typical ionic impurities (Na+，Mg2+，Ca2+andFe3+) on cobalamine crystallization is also studied. As a result，It is clear that Fe3+ and Mg2+ have more significant effect than Na+ and Ca2+ on crystal morphology using dilution crystallization.