The Synthesis of Novel Sulfur-containing Chiral Macrocyclic Multidentate Ligands

The biomimetic chemistry has aroused widespread interest in the past two decades^[l~4]. The molecular recognition property of chiral crown ether has attracted much attention, not only due to its wide applications to pharmaceutical science, catalysis, and separation technology but also because the inclusion process is considered an ideal model mimiching the enzyme-substrate interaction.