Synthesis of 3-(2-Phenylquinolin-4-yl)/3-(l-p-Chlorophenyl-5-methyl-1, 2,3-triazol-4-yl)-s-triazolo[3,4-b]-1, 3,4-thiadiazine Derivatives |
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Authors: | HUI Xin-Ping QIAO Ren-Zhong WANG Qin GONG Yan-Ni XU Peng-Fei ZHANG Zi-Yi |
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Institution: | 1. Department of Chemistry, Lanzhou University, Lanzhou 730000;
2. Department of Biology, Lanzhou University, Lanzhou 730000 |
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Abstract: | s-Triazolo3, 4-b]-1,3,4-thiadiazine derivatives constitute an important class of organic compounds with diverse biological activities. 2-Phenylquinoline and 1,2, 3-triazole derivatives are very attractive heterocyclic systems due to their wide use in medicine, agriculture and industry1]. Incorporation of 2-phenylquinoline and 1,2,3-triazole moiety into the 3-position of s-triazolo3,4-b]-l, 3,4-thiadiazine ring system may enhance their biological activity. In light of the above findings, we synthesized some new s-triazolo3, 4-b]-1, 3, 4-thiadiazine derivatives 2a-b~6a-b by the condensation of 4-amino-5-mercapto-3-(2-phenylquinolin-4-yl)/3-(1-p-chlorophenyl-5-methyl-1, 2,3-triazol-4-yl)-1, 2, 4-triazoles 1a-b with chloroacetalde-hyde, ω-bromo-ω-(1H-1, 2, 4-triazol-1-yl)acetophenone, chloranil, 2-bromocyclohexanone, 2, 4'-dibromoacetophenone, respectively. |
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