Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals |
| |
Authors: | Parthasarathi Subramanian |
| |
Institution: | Riddet Institute, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand; |
| |
Abstract: | Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment and have poor bioavailability. Application of a novel carrier system is of increasing importance to overcome obstacles and provide efficient applicability. Lipid-based nanocarriers provide a large surface-to-mass ratio, enhanced intestinal absorption by solubilization in the intestinal milieu, intestinal lymphatic transport, and altering enterocyte-based transport. A critical overview of the current limitation, preparation, and application of lipid-based nanocarriers (liposomes and niosomes) and lipid nanoparticles (SLNs and NLCs) is discussed. Physical and gastrointestinal stability and bioavailability of nanoencapsulated nutraceuticals are considered as well. |
| |
Keywords: | bioavailability liposomes niosomes physicochemical stability solid lipid nanoparticles polyphenols |
|
|