Synthesis and Biological Activity of Pyrazolo[5,1-d] [1,2,3,5]-Tetrazine-4-ones |
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Authors: | HU Fang-Zhong ZOU Xiao-Mao LI Yong-Hong YANG Hua-Zheng |
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Institution: | State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071 |
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Abstract: | It is reported that benzo1,2,3]-triazine-4-ones have widespread use, for instance, as diuretics, sedatives, tranquilizers and inflammation inhibitors and pyrazolo1,5-a]-1,3,5-triazines are potent inhibitors of xanthine oxidase. So far,the herbicidal activities of above fused ring compounds and their analogues have not been studied. According to the principle of bioisotherism, pyrazolo5,1-d] 1,2,3,5]-tetrazine-4-ones (2) have been developed and synthesized. |
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