A Convenient Synthesis of 2,5 (1H,3H)-Tetrahydroquinazolinedione Using Lanthanum Chloride as the Catalyst

In the past decade,4-aryl-3,4-dihydropyrimidine derivatives have exhibited important pharmacological properties, e.g. as the integral backbones of several calcium channel blockers, antihypertensive agents, alpha-1a-antagonists, and neuropeptide Y (NPY) antagonists^[1]. Several lead compounds were developed that are equal in potency and duration of antihypertensive activity to classical and second-generation dihydropyridine drugs^[2].