Interaction Studies Between Peroxovanadium Complexes and Model Peptide in Active Center of Tyrosine Phosphatase

Peroxovanadium(pV) complexes are potent protein tyrosine phosphatase inhibitors and possibly could be developed into a new kind of oral drugs for treatment of diabetes^1,2]. They have been paid considerable attention nowadays. Their action mechanism of insulin-mimetic effects involved in irreversibly oxidizing the catalytic cysteine of the enzyme according to the latest evidence^3]. However, little was studied on the structure-function relationship of pV complexes until our latest paper^4] in which we suggested that it related to the interaction between pV and functional groups in active center of tyrosine phosphatase except for their oxidizing ability. In order to convince our assumption, histidine and glutathione with model functional groins of imidazole and sulfhydryl residue in the active domain of target enzyme^5] were selected as study object of interaction with pV complexes.