The Effect of Chemical Structure on the DNA Binding Behavior of Tricyclic Heteroaromatic Ligands |
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Authors: | WANG Xue-Mei LI Yao JIANG Xian-Hun |
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Affiliation: | 1. The State Key Lab of Coordination Chem., Nanjing University, Nanjing 210093;2. National Lab of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096 |
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Abstract: | It is well-known that small organic ligands can bind to the double-stranded nucleic acids by three modes, i.e.s grooving binding, intercalation, and electrostatic binding. Usually, intercalation of the ligands into the double helix involves the insertion of a planar atomatic cation into base stack of the helix, while groove binding of small molecules is pertaining to the docking of thin ribbon-like molecules in the minor groove of the helix. In both cases, electrostatic and hydrophobic interactions can afford additional stabilization for the binding. |
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