Study on the Dye-Doped Funcionalized Silica Nanoparticles for The Recognition of SmIgG+B Lymphocytes

The development of sensitive non-isotopic detection sys tem for biological and medicinal applications, such as single cell analyse, DNA sequence, clinical diagnose etc., has driven nanomaterials more towards cell biology and ultrasensitive immunoassay^1]. Semiconductor nanoparticles have been used for coupling biomolecules but suffer from some disadvantages including poor solubility in water, blinking properties or low quantum yields^1,3,4]. In this paper, we developed a novel dye-doped functionalized silica nanoparticles and used for detection of SmIgG⁺ B lymphocytes.