Synthesis and Theoretical Studies of Phosphoryl Amino Acid Analogue

Phosphoryl amino acids and their analogues are continuing to be increasingly important as potential enzyme inhibitors, mechanistic probes for proteases^1,2]. Previously, a series of investigations on the structure-reactivity relationship about phosphoryl amino acids 1 had been carried out, the results showed that the co-participation of phosphoryl group, carboxyl group and residues of amino acids were essential and their biomimic reaction mechanisms were commonly through a penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates^3].