An Asymmetric Synthesis of Isoindolinones |
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Authors: | CHEN Ming-De HUANG Li-Qiang HUANG Pei-Qiang |
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Institution: | Department of Chemistry, Xiamen University, Xiamen 361005 |
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Abstract: | Recently, the results from this laboratory showed that the reductive alkylation of protected (S)-malimide could be achieved in a high regio- and diastereoselective manner. The substituted 2-pyrrolidinones thus formed are versatile chiral building blocks which can be used in the asymmetric synthesis of pyrrolidines1,2],2-pyrrolidinones3,4] and β-hydroxy-γ-amino acids5,6]. As an extension of this work, and in combination with the current interest in the synthesis of isoindolin-1-ones, a study on the asymmetric reductive alkylation of phthalimide derived from (R)-phenylglycinol was undertaken. |
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