Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla |
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| Authors: | Xiaoli Ma Hongwei Chen Sisi Zhu Pengfei Tu Yong Jiang |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China; (X.M.); (H.C.); (S.Z.); (P.T.) |
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| Abstract: | Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A–O (2–16), and a C-6–C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids were obtained by chiral HPLC separation and their absolute configurations were determined by electronic circular dichroism (ECD) data analysis. |
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| Keywords: | Murraya microphylla trimeric carbazole dimeric carbazole racemates absolute configurations ECD |
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