Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment |
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Authors: | Gaggelli Elena Grzonka Zbigniew Kozłowski Henryk Migliorini Caterina Molteni Elena Valensin Daniela Valensin Gianni |
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Institution: | Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy. |
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Abstract: | The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex. |
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