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Biodegradable polymeric nanoparticles based on amphiphilic principle: construction and application in drug delivery
Authors:ShiYong Zhang  Yao Wu  Bin He  Kui Luo  ZhongWei Gu
Affiliation:1. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China
Abstract:The use of nanotechnology in drug-delivery systems (DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.
Keywords:biodegradable polymer  micelle  amphiphilicity  drug-delivery system  cancer
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