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A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis |
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| Authors: | Zhong Zhao Dale J Lange Andrei Voustianiouk Donal MacGrogan Lap Ho Jason Suh Nelson Humala Meenakshisundaram Thiyagarajan Jun Wang Giulio M Pasinetti |
| Institution: | (1) Neuroinflammation Research Laboratories, Department of Psychiatry, USA;(2) Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1668, New York, 10029, USA;(3) Bronx Veterans Affairs Medical Center, 130 W Kingsbridge Road, Bronx NY, 10468, USA |
| Abstract: | BackgroundThe cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization. |
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