| The selective recognition of mismatched d(GCGAGC)_2 by the cobalt(III) complex |
| |
| 作者姓名： | CHEN Huili & YANG Pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan China |
| |
| 作者单位： | CHEN Huili & YANG Pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education，Institute of Molecular Science，Shanxi University，Taiyuan 030006，China |
| |
| 基金项目： | 国家自然科学基金，山西省自然科学基金 |
| |
| 摘 要： | Base mismatches arise naturally in the life cycleof a cell as a result of either polymerase error or DNAdamage. Under most circumstances the cell correctsthese mispairings using a complex repair system toprevent mutations in the genetic code. Experimental…
|
The selective recognition of mismatched d(GCGAGC)2 by the cobalt(III) complex |
| |
| CHEN Huili & YANG Pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan ,China.The selective recognition of mismatched d(GCGAGC)_2 by the cobalt(III) complex[J].Science in China(Chemistry),2005,48(1). |
| |
| Authors: | Chen Huili YANG Pin |
| |
| Institution: | Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China |
| |
| Abstract: | We studied the binding of Co(phen)2(HPIP)]Cl3 to mismatched d(GCGAGC)2 con- taining two sheared G:A mispairs by NMR. The result shows that the complex was intercalated into G:A region from the minor groove and extended to the major groove, and could selectively recognize the mispairs. 31P NMR indicates that the complex binding induced the change of the phosphate backbone in the mismatched base pairs region. |
| |
| Keywords: | cobalt complex mismatched DNA mispairing recognition |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
