| 三聚氰胺甲醛微球的制备及模板法构建聚谷氨酸基微胶囊 |
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| 引用本文： | 张瑛,颜世峰,饶水琴,郑嬿珍,尹静波,陈学思.三聚氰胺甲醛微球的制备及模板法构建聚谷氨酸基微胶囊[J].高等学校化学学报,2011,32(10):2447-2452. |
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| 作者姓名： | 张瑛 颜世峰 饶水琴 郑嬿珍 尹静波 陈学思 |
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| 作者单位： | 1. 上海大学高分子材料系, 上海 201800;
2. 中国科学院长春应用化学研究所, 高分子物理与化学国家重点实验室, 长春 130022 |
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| 基金项目： | 国家自然科学基金(批准号:51003055,50973060); 上海市教育委员会科研创新项目(批准号:11YZ06); 上海市重点学科项目(批准号:s30107)资助 |
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| 摘 要： | 以分散聚合法制备低交联度三聚氰胺甲醛(MF)微球, 研究了pH和反应时间等对MF微球粒径、表面电位和溶解性的影响. 以MF微球为模板, 采用层层自组装法交替吸附聚谷氨酸(PGA)和壳聚糖(CS), 构建中空的PGA/CS微胶囊. 采用偏光显微镜、纳米粒度及电位分析仪、红外和透射电镜等进行表征. 结果表明, MF粒径及表面电位随pH值降低而减小, 在盐酸中的溶解性随反应时间延长而变差. 在自组装过程中, 微球表面电位呈正负交替变化, 表明以静电力为主要驱动力制得的空心微胶囊粒径均匀, 分散良好, 模型药物罗丹明可成功载入其中, 有望成为优良的水溶性药物载体.
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| 关 键 词： | 三聚氰胺甲醛微球 聚谷氨酸 微胶囊 自组装 ζ电位 |
| 收稿时间： | 2010-10-13 |
Preparation of Melamine-formaldehyde Microspheres and Microcapsules Based on Poly(glutamic acid) by Template Method |
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| ZHANG Ying,YAN Shi-Feng,RAO Shui-Qin,ZHENG Yan-Zhen,YIN Jing-Bo,CHEN Xue-Si.Preparation of Melamine-formaldehyde Microspheres and Microcapsules Based on Poly(glutamic acid) by Template Method[J].Chemical Research In Chinese Universities,2011,32(10):2447-2452. |
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| Authors: | ZHANG Ying YAN Shi-Feng RAO Shui-Qin ZHENG Yan-Zhen YIN Jing-Bo CHEN Xue-Si |
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| Institution: | 1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |
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| Abstract: | Melamine-formaldehyde(MF) microspheres were prepared by dispersion polymerization.The inf-luences of pH value and reaction time on partical size,surface potential and solubility of MF microspheres were studied.Using MF microspheres as templates,hollow PGA/CS microcapsules were fabricated by layer-by-layer self-assembly technique.The templates and microcapsules were characterized by polarization microscope,nano-granularity and potential analyzer,IR and TEM.The results show that the partical size and surface ... |
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| Keywords: | Melamine-formaldehyde(MF) Poly(glutamic acid) Microcapsule Assembly technique ζ-potential |
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