| 栓塞型新型微包纳药物控释载体的制备及性能 |
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| 引用本文： | 刘源岗,毛鸿浩,王士斌,孙学战. 栓塞型新型微包纳药物控释载体的制备及性能[J]. 高等学校化学学报, 2011, 32(11): 2574-2580 |
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| 作者姓名： | 刘源岗 毛鸿浩 王士斌 孙学战 |
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| 作者单位： | 1. 华侨大学化工学院, 2. 生物材料与组织工程研究所, 厦门 361021 |
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| 基金项目： | 国家“八六三”计划项目(批准号:2006AA02A118); 国家自然科学基金(批准号:31000441,31170939); 中央高校基本科研业务费(批准号:JB-JC1009,JB-SJ1009); 福建省自然科学基金(批准号:2009J01253,2011J01223)资助 |
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| 摘 要： | 为了抑制药物的突释效应, 减缓药物的释放速率, 实现不同药物的空间分配及顺序释放, 采用乳化法结合高压静电液滴法, 制备了内部包埋有几丁聚糖/海藻酸钙纳米囊的聚精氨酸/几丁聚糖/海藻酸盐微包纳体系(Nano-in-micro drug delivery system, NiM). 通过荧光标记的方法证实了“微包纳”结构并考察了NiM的理化性能. 以牛血清白蛋白及氟尿嘧啶作为药物模型, 考察了聚精氨酸/几丁聚糖/海藻酸盐微包纳体系对单一蛋白类药物和负载两种药物的缓释性能并进行了动力学模型拟合. 结果表明, Ritger-Peppas模型能够较好地模拟该溶胀控释系统的药物释放过程, 与实验结果比较吻合. 同时也证明了该新型载体体系具有无突释、释放速率减缓及顺序释放的功能, 为新型药物载体体系的研究提供了新的思路.
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| 关 键 词： | 微包纳药物释放体系 ,聚精氨酸 ,海藻酸钠 ,几丁聚糖 ,顺序释放, |
| 收稿时间： | 2010-11-10 |
Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System |
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| LIU Yuan-Gang,MAO Hong-Hao,WANG Shi-Bin,SUN Xue-Zhan. Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System[J]. Chemical Research In Chinese Universities, 2011, 32(11): 2574-2580 |
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| Authors: | LIU Yuan-Gang MAO Hong-Hao WANG Shi-Bin SUN Xue-Zhan |
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| Affiliation: | 1. College of Chemical Engineering, 2. Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China |
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| Abstract: | A novel poly-L-arginine/chitosan/calcium alginate nano-in-micro(NiM) drug delivery system was prepared using emulsification combined with electrospraying method.Fluorescent labelling test proved that the nano-in-micro structure of NiM was successfully constructed.Bovine serum albumin(BSA) and 5-FU were used as model drugs and the release profiles of NiM as carriers to a single drug and two different drugs were investigated respectively.The results show that the cumulative release rates are 16.3%(5-FU) and 4... |
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| Keywords: | Nano-in-micro drug delivery system Poly-L-arginine Sodium alginate Chitosan Sequential release |
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