基于异源自分类串联反应集成策略构筑不对称的1,4-二氢吡啶衍生物

假设不同结构的底物可以同时参与自分类的串联反应，而且各自生成的合适官能化的分子能够进一步发生汇聚反应，将更为有效地制备复杂的产物。在此基础上，我们建立了一个简单的反应模型来验证该策略的可行性。例如，在醋酸铵和间硝基苯甲醛的存在下，两种1,3-二羰基化合物可以经过两个并存的串联反应路径分别生成烯胺和烯酮中间体，二者随后汇聚选择性生成不对称的1,4-二氢吡啶.通过核磁直接检测反应液进一步证实了该反应的高度选择性，即不同底物发生串联反应的高度自分类且汇聚的特性.我们希望该结果能启发化学家通过更为有效的异源自分类串联反应集成策略实现由简单底物来高效制备复杂的分子.

Construction of Unsymmetrical 1,4-Dihydropyridines via Integration of Hetero-source Self-sorting Domino Reactions

On the hypothesis that hetero-sources could involve in self-sorting domino reactions and generate suitably functionalized intermediates to converge on the final product,we present herein a simple model of this strategy for the preparation of unsymmetrical 1,4-dihydropyridines.In the presence of CH3COONH4 and 3-nitrobenzaldehyde,two different 1,3-dicarbonyl compounds,respectively,generate the enamine and enone intermediates,which could finally combine with each other to efficiently afford the unsymmetrical 1...