| 一种两亲性嵌段共聚物胶束的制备及其对叶酸的负载和控制释放 |
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| 引用本文： | 王磐,翟翠萍,袁金芳,高青雨. 一种两亲性嵌段共聚物胶束的制备及其对叶酸的负载和控制释放[J]. 高分子学报, 2011, 0(12): 1361-1367 |
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| 作者姓名： | 王磐 翟翠萍 袁金芳 高青雨 |
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| 作者单位： | 河南大学精细化学与工程研究所; |
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| 基金项目： | 国家自然科学基金(基金号50273010)资助项目 |
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| 摘 要： | 采用可逆加成-断裂链转移(RAFT)聚合合成了以丙烯酸异丁酯(IBA)、甲基丙烯酸2-二甲氨乙酯(DMAEMA)无规共聚嵌段与聚丙烯酸-2-羟丙酯(PHPA)组成的两亲性两嵌段共聚物(P( IBA-co-DMAEMA)-b-PHPA),并用凝胶渗透色谱(GPC)、核磁共振波谱(1H-NMR)及红外光谱(FTIR)对其进...
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| 关 键 词： | 两亲性嵌段共聚物 胶束 制备 高负载药物容量 叶酸控制释放 |
PREPARATION OF MICELLES FROM AN AMPHIPHILIC BLOCK COPOLYMER AND THEIR LOADING AND CONTROLLED RELEASE OF FOLIC ACID |
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| WANG Pan,ZHAI Cuiping,YUAN Jinfang,GAO Qingyu. PREPARATION OF MICELLES FROM AN AMPHIPHILIC BLOCK COPOLYMER AND THEIR LOADING AND CONTROLLED RELEASE OF FOLIC ACID[J]. Acta Polymerica Sinica, 2011, 0(12): 1361-1367 |
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| Authors: | WANG Pan ZHAI Cuiping YUAN Jinfang GAO Qingyu |
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| Affiliation: | WANG Pan,ZHAI Cuiping,YUAN Jinfang,GAO Qingyu(Institute of Fine Chemical and Engieering,Henan University,Kaifeng 475001) |
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| Abstract: | A novel of amphiphilic diblock copolymer(P(IBA-co-DMAEMA)-b-PHPA),which composed of poly(isobutyl acrylate-co-2-(N,N-dimethylamino)ethyl methacrylate) random copolymer block and poly(2-hydroxypropyl acrylate),was synthesized by reversible addition-fragmentation chain transfer(RAFT) polymerization,and its structure and composition were confirmed by gel permeation chromatography(GPC),1H nuclear magnetic resonance(1H-NMR) spectroscopy and FTIR spectroscopy.This copolymer could self-assemble into stable polymer... |
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| Keywords: | Amphiphilic block copolymer Micelles Preparation High drug-loaded capacity Control of folic acid release |
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