| 瓜环类超分子药物载体的研究进展 |
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| 引用本文： | 黄英,陶朱,薛赛凤,祝黔江. 瓜环类超分子药物载体的研究进展[J]. 高等学校化学学报, 2011, 32(9): 2022-2031 |
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| 作者姓名： | 黄英 陶朱 薛赛凤 祝黔江 |
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| 作者单位： | 1. 贵州大学贵州省大环化学及超分子化学重点实验室, 2. 西南药用生物资源教育部工程研究中心, 贵阳 550025 |
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| 基金项目： | 国家自然科学基金(批准号:20972034); 贵州省省长资金(批准号:黔省专合字(2009)103号); 贵州省科技厅自然科学基金(批准号:黔科合J字[2009]2288号); 贵州省教育厅自然科学基金(批准号:黔教科2010013); 贵州大学引进人才项目[批准号:贵大人基合字(2009)023号]资助 |
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| 摘 要： | 瓜环具有“内疏水、外亲水”的特殊分子结构，可以多种有机物发生主客体相互作用而形成自组装分子胶囊或超分子实体，使其在环境、医药、化学分离、材料的改性等方面都有着广泛的应用前景。本文结合自己的工作，参考国内外文献综述了瓜环在药物载体及药物传输方面的研究进展，并就瓜环在药物领域的发展作一展望。
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| 关 键 词： | 瓜环 药物载体 药物传输 |
| 收稿时间： | 2011-03-29 |
Progress of Cucurbit[n]urils in Drug Delivery System |
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| HUANG Ying,TAO Zhu,XUE Sai-Feng,ZHU Qian-Jiang. Progress of Cucurbit[n]urils in Drug Delivery System[J]. Chemical Research In Chinese Universities, 2011, 32(9): 2022-2031 |
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| Authors: | HUANG Ying TAO Zhu XUE Sai-Feng ZHU Qian-Jiang |
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| Affiliation: | 1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, ;2. Engineering and Research Center for Southwest Bio|pharmaceutical Resources, Ministry of Education, Guizhou University, Guiyang 550025, China |
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| Abstract: | Many drug delivery systems are based on the ability of certain macrocyclic compounds,such as cyclodextrins(CDs),to act as molecular containers for pharmaceutical agents in water.Cucurbit[n]urils(Q[n]) which have the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals,are a class of molecular containers that bind to a variety of cationic and neutral species with high affinity and therefore show great promise as a drug delivery system.In this review,we traced the developmen... |
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| Keywords: | Cucurbit[n]uril Drug carrier Drug delivery |
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