| 聚电解质微球多级自组装制备双重药物载体 |
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| 引用本文： | 卫兰,蔡春华,林嘉平.聚电解质微球多级自组装制备双重药物载体[J].高分子学报,2011(12):1461-1469. |
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| 作者姓名： | 卫兰 蔡春华 林嘉平 |
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| 作者单位： | 华东理工大学材料科学与工程学院上海市先进聚合物材料重点实验室; |
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| 基金项目： | 国家自然科学基金(基金号50925308)资助项目 |
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| 摘 要： | 将表面带正电荷的壳聚糖(CS)微球和表面带负电荷的聚(L-谷氨酸)-b-聚氧化丙烯-b-聚(L-谷氨酸)(GPG)胶束共混,制备了CS/GPG聚集体水溶液体系.通过改变CS/GPG的共混比例,研究了CS微球和GPG胶柬形成稳定CS/GPG聚集体水溶液体系的配比范围,并对其粒径分布和表面电位进行了表征.在此基础上,将CS...
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| 关 键 词： | 壳聚糖 胶束 静电自组装 多级自组装 双重载药 |
DUAL DRUG DELIVERY SYSTEM FROM MULTI-STEP SELF-ASSEMBLED POLYELECTROLYTE NANOPARTICLES |
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| WEI Lan,CAI Chunhua,LIN Jiaping.DUAL DRUG DELIVERY SYSTEM FROM MULTI-STEP SELF-ASSEMBLED POLYELECTROLYTE NANOPARTICLES[J].Acta Polymerica Sinica,2011(12):1461-1469. |
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| Authors: | WEI Lan CAI Chunhua LIN Jiaping |
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| Institution: | WEI Lan,CAI Chunhua,LIN Jiaping(Shanghai Key Laboratory of Advanced Polymeric Materials,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237) |
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| Abstract: | Self-assembly of chitosan(CS) particles and poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid)(GPG) triblock copolymer micelles was investigated.The CS particles are cationic hydrogels,while the GPG micelles have anionic poly(L-glutamic acid) shells.Therefore,the two kinds of polyelectrolyte particles can electrostatic self-assemble into microscopic CS/GPG conjugates.The CS/GPG ratio range for the CS particles and GPG micelles to electrostatic self-assemble into a sustained CS/GPG conjuga... |
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| Keywords: | Chitosan Micelles Electrostatic self-assembly Multi-step self-assembly Dual-drug delivery |
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