| 组分对含羟基磷灰石/脂肪族聚氨酯复合骨组织工程支架的理化性能及生物学性能的影响 |
| |
| 引用本文： | 王立,左奕,邹琴,李玉宝.组分对含羟基磷灰石/脂肪族聚氨酯复合骨组织工程支架的理化性能及生物学性能的影响[J].高等学校化学学报,2011,32(10):2453-2459. |
| |
| 作者姓名： | 王立 左奕 邹琴 李玉宝 |
| |
| 作者单位： | 四川大学纳米生物材料研究中心,分析测试中心,成都610064 |
| |
| 基金项目： | 国家“九七三”计划项目(批准号:2007CB936102); 国际科技合作和与交流专项(中荷战略联盟项目)(批准号:2008DFB50120); 国家自然科学基金(批准号:50972096)资助 |
| |
| 摘 要： | 以异佛尔酮二异氰酸酯为聚氨酯硬段,通过原位聚合使聚合过程中释放的气体发泡,制备了用作骨组织工程材料的羟基磷灰石/脂肪族聚氨酯多孔支架.系统考察了不同组成配方,即羟基磷灰石(HA)含量、发泡剂含量以及聚氨酯(PU)软硬段的比例对三维支架材料的机械性能和微观孔隙结构等的影响,并通过体外细胞培养和体内肌肉植入初步评价了该复合...
|
| 关 键 词： | 骨组织工程支架 羟基磷灰石 脂肪族聚氨酯 组分影响 生物学性能 |
| 收稿时间： | 2010-10-11 |
Effect of Composition on Physical-chemical Properties and Biological Properties of Hydroxyapatite/Aliphatic Polyurethane Scaffolds for Bone Tissue Engineering |
| |
| WANG Li,ZUO Yi,ZOU Qin,LI Yu-Bao.Effect of Composition on Physical-chemical Properties and Biological Properties of Hydroxyapatite/Aliphatic Polyurethane Scaffolds for Bone Tissue Engineering[J].Chemical Research In Chinese Universities,2011,32(10):2453-2459. |
| |
| Authors: | WANG Li ZUO Yi ZOU Qin LI Yu-Bao |
| |
| Institution: | WANG Li,ZUO Yi*,ZOU Qin,LI Yu-Bao(Research Center for Nano-Biomaterials,Analytical and Testing Center,Sichuan University,Chengdu 610064,China) |
| |
| Abstract: | Aliphatic polyurethane(PU) and hydroxyapatite(HA) composite scaffolds were prepared by in-situ polymerization and gas self-foaming process.The morphologies and properties of the scaffolds were studied by varying the contents of HA,foaming agent(water) and soft/hard segment ratio and characterized by scanning electron microscope(SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR) and mechanical test.The results show that the compressive strength of the scaffolds increased with both the ... |
| |
| Keywords: | Bone tissue engineering scaffold Hydroxyapatite Aliphatic polyurethane Effect of composition Biological property |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
| 点击此处可从《高等学校化学学报》下载免费的PDF全文 |
