Design of organocatalysts for asymmetric direct syn-aldol reactions |
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| Authors: | Xu Xiao-Ying Wang Yan-Zhao Gong Liu-Zhu |
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| Institution: | Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. |
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| Abstract: | Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-beta-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities of up to 99% ee. |
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