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Synthesis of Functionalized Spiro[cycloalkanono-2,3'-thiophenes] via Tandem Conjugate Addition-Cyclization of 3-Oxoacid Thioanilides to Nitroalkenes
Authors:Krystyna Bogdanowicz-Szwed and Regina Gil
Institution:(1) Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Krak?w, Poland;(2) Andrzej Frycz Modrzewski Krakow University, Krak?w, Poland;(3) Regional Laboratory, Jagiellonian University, Krak?w, Poland;
Abstract:A convenient method is described for the synthesis of functionalized spirocycloalkanono-2,3prime-thiophenes] by treatment of cyclic 3-oxoacid thioanilides with beta-nitrostyrenes. Reaction of the obtained products with acetic anhydride yielded the corresponding oxime acetates.
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