Amidomethylation of the benzene ring of indoles |
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| Authors: | L. G. Yudin M. Abdullaev A. N. Kost |
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| Affiliation: | (1) M. V. Lomonosov Moscow State University, 117234 Moscow;(2) Andizhan Pedagogical Institute, 710000 Andizhan |
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| Abstract: | The benzene ring of indoles was amidomethylated by various agents in the presence of sulfuric acid. The amidomethylation of 2-methyl- and 2,3-dimethylindoles takes place in the 5 position. When there is a methyl or methoxy group in the 5 or 7 position, the substituent enters the 6 position. Hydrazinolysis or hydrolysis of the amidomethylation products gives 5- or 6-aminomethylindoles.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1066–1069, August, 1978. |
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