Photosensitizer in a molecular bowl: steric protection enhancing the photonuclease activity of copper(II) scorpionates |
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Authors: | Dhar Shanta Chakravarty Akhil R |
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Institution: | Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. |
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Abstract: | Steric encumbrance caused by the tripodal ligand in the ternary tris(3-phenylpyrazolyl)borate copper(II) heterocyclic base complexes Cu(B)(Tp(Ph))](ClO(4)) (B = dipyridoquinoxaline, dipyridophenazine) leads to efficient cleavage of supercoiled DNA to its relaxed form upon exposure to red light at 632.8 and 694 nm as a result of protection of the photosensitizer in the molecular bowl of the {Cu(Tp(Ph))} moiety, which generates singlet oxygen as the reactive species in a type-II process. |
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